Early-Stage Investigators Policies How to Apply - Application Guide NIH Forms & Applications NIH Grants YouTube Channel NIH Research Grant Mechanisms Relevance of the proposed research to NIGMS priorities. You might also consider participating in the NIH Center for Scientific Review's. Only those application types listed here are allowed for this NOFO. Other Attachments: The application must include the following attachment. New investigators are encouraged to apply for an R01 (see NOT-OD-09-013, "Revised New and Early Stage Investigator Policies) or an R03 (see NIAMS Small Grant Program for New Investigators). It is possible to get exceptions for interruptions in your career due to the birth of a child and other situations. Plan to utilize the project infrastructure (i.e., research and structure) to support career-enhancing research opportunities for diverse junior, early- and mid-career researchers. Twitter The overall evaluation of the program will be based on metrics that may include, but are not limited to, the following: We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants. We are particularly interested in applications from physician-scientists. See NOT-AR-10-023 for additional information regarding NIAMS support for innovative research using R21 grants. Awardees will provide updates at least annually on implementation of the PEDP. There are many benefits that flow from a broad scientific workforce, including: fostering scientific innovation, enhancing global competitiveness, contributing to robust learning environments, improving the quality of the research, advancing the likelihood that underserved populations participate in, and benefit from research, and enhancing public trust. WebThe Stephen I. Katz Early Stage Investigator Research Project Grant supports an innovative project in an area of science that represents a change in research direction for an early A PD/PI may submit an R01 application and a MIRA application within the same council round. Application content: Investigational New Drug or Investigational Device Exemption Requirements: Consistent with federal regulations, clinical research projects involving the use of investigational therapeutics, vaccines, or other medical interventions (including licensed products and devices for a purpose other than that for which they were licensed) in humans under a research protocol must be performed under a Food and Drug Administration (FDA) investigational new drug (IND) or investigational device exemption (IDE). An Early Stage Investigator (ESI) is a new investigator who has completed his or her terminal research degree or medical residencywhichever date is laterwithin the past 10 years and has not yet competed successfully for a substantial, competing NIH research grant. Letters of support from collaborators must be limited to 1 page each, must not include attached Biographical Sketches, and should not circumvent page limitations by includingfigures and data. Outreach and planned engagement activities to enhance recruitment of individuals from diverse groups as research participants including those from under-represented backgrounds. Letters of Support: A letter of support must be included from the department chair, dean, or other academic unit leader that describes institutional commitment to the development of the investigator and any other pertinent information. Candidate Information and Goals for Career Development attachment (2-page limit): In lieu of preliminary data from the PD/PI's independent lab, feasibility of the program may be demonstrated through literature citation, data from other sources, or data generated by the applicant as a graduate student or postdoctoral fellow. Web1. Supplement requests should be submitted electronically. For trials focusing on clinical or public health endpoints, is this clinical trial necessary for testing the safety, efficacy or effectiveness of an intervention that could lead to a change in clinical practice, community behaviors or health care policy? Does the application propose to use existing available resources, as applicable? Characteristics of the applicant and awardee pool for the program, such as: Number of ESI PD/PIs who apply for MIRA instead of R01s, Geographic distribution of Investigator demographics. First Competitive Renewal of R01 Applications From Former NIDDK ESIs NIDDK seeks to encourage the stable integration of early career researchers into the scientific research workforce. Reduce the time spent by researchers writing and reviewing grant applications, allowing them to spend more time conducting research. A description of any additional funds available to ensure sustained research and the availability of carryover funds from previous years and any local assistance, including matching funds or specified 'in kind' support. The total research effort should include the PD/PI's combined research effort at all institutions where the PD/PI holds an appointment, should be expressed in person-months, and should not include time expended toward teaching or administration not directly related to the PD's/PI's research, and/or clinical duties. Letters from former mentors are not required, nor encouraged, except in the case of continuing collaborations. Scientific and technical merit of the proposed research program as determined by scientific peer review. Are the timeline and milestones associated with the Plan for Enhancing Diverse Perspectives well-developed and feasible? Transfer of a MIRA to a foreign institution will not be allowed. Eligibility Investigators may not apply for an ESI MERIT Award. Notices of Special Interest associated with this funding opportunity. Contributions to Science: This section of the biosketch should emphasize contributions over the past five years. The NIAMS has very limited funds for such supplements, and approves such requests infrequently. Further information concerning these requirements is found at http://grants.nih.gov/grants/policy/hs/data_safety.htm and in the application instructions (SF424 (R&R) and PHS 398). Please see https://www.hhs.gov/civil-rights/for-providers/provider-obligations/index.html and https://www.hhs.gov/civil-rights/for-individuals/nondiscrimination/index.html. The NIAMS welcomes applications to the NIH Loan Repayment Program. Email:support@grants.gov, Sailaja Koduri, Ph.D.National Institute of General Medical Sciences (NIGMS)Email: sailaja.koduri@nih.gov, Maqsood Wani, Ph.D.Center for Scientific Review (CSR)Email: wanimaqs@csr.nih.gov, Lisa MoellerNational Institute of General Medical Sciences (NIGMS)Email: moellerl@mail.nih.gov. Larger award amount than the current average NIGMS R01 award to ESIs. Provide a rationale for the changes in the context of the originally proposed research program and explain how the research continues to fit within NIGMS mission interests. Is the prior research that serves as the key support for the proposed research rigorous? In 1998, NIGMS established procedures and funding policies to ensure support for adequate numbers of new investigators (defined as a research applicant who has not yet been awarded a substantial, competing NIH grant). Does the design/research plan include innovative elements, as appropriate, that enhance its sensitivity, potential for information or potential to advance scientific knowledge or clinical practice? Women, individuals from underrepresented racial and ethnic groups, from disadvantaged backgrounds, or with disabilities (NOT-OD-22-019) are always encouraged to apply for NIH support. Enable investigators to apply earlier in their independent research careers, allowing them to secure grant funding that will launch and sustain productive research careers. Under these policies, an applicant's status as a new investigator is one of the criteria used in funding decisions made by the Institute. Provide the total consortium/subaward costs for each budget period listing the total direct costs and indirect (F&A) costs separately. For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this NOFO. To be eligible, PIs must hold an active NIAMS K award. 2. An application does not need to be strong in all categories to be judged likely to have major scientific impact. Preliminary dataare not required and justification for the proposed work may be provided through literature citations, data from other sources, or data generated by the applicant as a graduate student or postdoctoral fellow. For individuals identified as NIs, the software will calculate the ten-year window of Early Stage Investigator (ESI) status based on the date of the terminal research degree or the residency end date entered in the investigators Profile. An Early Stage Investigator (ESI) is a New Investigator who is within 10 years of completing the terminal research degree or within 10 years of completing medical residency or equivalent. Form Approved OMB# 0925-0648 Exp. A permanent change of PD/PI will not be allowed under the MIRA. 318-286-3599. Candidates must be clinician-scientists working in a research environment, conducting patient-oriented research. WebNIDDK has established R01 paylines for five classes of applications: 1) general applications requesting less than $500K, 2) applications requesting more than $500K, 3) New Investigator applications, 4) ESI applications, and 5) ESI First Competitive Renewal applications. Consistent with the NIH NGRI, NIMHD seeks to encourage the stable integration of early stage investigators (ESIs) into the scientific research workforce. All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form. Applications with multiple PDs/PIs will not be accepted. In case of changes in employment of the PD/PI (e.g., accepting an appointment at another institution, while retaining an appointment at the institution which received the MIRA award), the PD/PI is required to maintain their commitment to MIRA as originally reviewed and approved. The mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress in these diseases. Applicants are encouraged to send an e-mail to the scientific contact alerting them to the submission of the application: marisol.espinoza-pintucci@nih.gov. The following items are to be included in the PH 398 Research Plan Form: 2. The NIGMS MIRA differs from other institutes' R35 awards in that MIRA is not a grant designed to support a small number of investigators; instead, the Institute intends to have at least 60% of the R01-equivalent pool eventually be MIRAs as stated in the Institute's strategic plan. Description of any planned partnerships that may enhance geographic and regional diversity. is acting as the primary caregiver for an ailing spouse, child, partner, or a member of the immediate family. In addition to research designed to answer scientific questions and generate new ideas and hypotheses, the development of technology and computational approaches are supported. Supplement applications submitted to NIAMS must provide documentation that, at the time of the award, the PI: Only one parent at a time can be designated as the primary caregiver to a child. Refer to Part 1 for dates for peer review, advisory council review, and earliest start date. Similarly, early career stage applicants may not have yet published independently as senior or corresponding authors, and the absence of these publications should not be viewed as a weakness. Is the trial appropriately designed to conduct the research efficiently? Research Strategy (6-page limit) to include: 2. Refer to NIH's Early Stage Investigator policies for information about what awards impact ESI status. After the PD/PI's ESI eligibility has expired, they may be eligible to apply to the MIRA for Established and New Investigators as a new investigator. A final RPPR, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement. A PD/PI may submit a research project grant application (i.e., R01) and an ESI MIRA application for the same council round. That said, if your institution assigns you to become a principal investigator (PI) on an existing grant that you did not apply for, you still qualify as new. Is the environment conducive for the PD/PI to develop as an independent researcher? Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Is there a logical plan for sustained progress across a research program for the five-year award period? ORWH works in partnership with the NIH Institutes as well as the Food and Drug Administration (FDA) to ensure that women's health research is part of the scientific framework at NIH and throughout the scientific community. The PEDP should provide a holistic and integrated view of how enhancing diverse perspectives is viewed and supported throughout the application and can incorporate elements with relevance to any review criteria (significance, investigator(s), innovation, approach, and environment) as appropriate. NIAMS strongly recommends applicants submit an X02 pre-application.Duration: up to 2 years for the R61 Phase and 1 year for the R33 PhaseBudget Cap: $250,000 direct costs per yearApplications Due: By RFA only, Applicant Information Webinar for NIAMS Research Innovations for Scientific Knowledge (RISK) (X02, R61/R33), FAQsNIAMS Research Innovations for Scientific Knowledge (RISK) (X02, R61/R33), Active Resource-based P30 funding opportunities, Provides critical research infrastructure, shared facilities, services, and resources to groups of investigators, with the broad overall goal of accelerating, enriching, and enhancing the effectiveness of ongoing basic, translational, and clinical research and promoting new research within the NIAMS mission. Only single PD/PI applications are allowed. Junior investigators include NIH-defined Early Stage Investigator, New Investigator, and Early Established Investigator. In addition, when NIs or ESIs receive their first grant they are encouraged to maintain contact with their Program Official who can be an excellent resource during this critical stage of your research career. If there are further questions, applicants should consult with the NIGMS Scientific/Research staff (listed in Section VII. For additional information on review of the Human Subjects section, please refer to the Guidelines for the Review of Human Subjects. FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award. b) Under Section B.4, Opportunities for Training and Professional Development, indicate if individual development plans have been used for any graduate students and/or post-doctoral fellows supported by this award. WebYes, ESIs that are awarded a grant under this FOA will lose their ESI status, because it is an R01 award. Open Mike: Introducing the Stephen I. Katz Early Stage Investigator Research Grant Program. The BTOD award can only provide support in a MIRA PD/PI's laboratory for late-stage technology development and dissemination efforts. Is the process for obtaining informed consent or assent appropriate? Applications that are incomplete or non-compliant, or that do not fall within the NIGMS mission, will not be reviewed. NIAMS strongly encourages the PI of the parent research grant to contact both the scientific contact listed in this table and the NIAMS Program Officer of that grant. Applicants who receive funding as the PD/PI of an R01, RM1, SC1, DP1, DP2, or any other type of disqualifying award, including certain ones listed above, prior to issuance of the ESI MIRA become ineligible to receive the award. Applications due: Standard datesAdditional Information: Active R03 funding opportunity: PAR-22-119 More widely distribute funding among the nation's highly talented and promising investigators to increase overall scientific productivity and the chances for important breakthroughs. Summary statements for new investigator R01 applications are prioritized, and when possible, released before summary statements for other applications reviewed in the same meeting. For additional information and application due dates, see the FOA here: PA-18-914 Does my renewed NHLBI R01 award qualify as an NHLBI-funded NIH Early Stage Investigator award and therefore meet that eligibility criterion for the Emerging Investigator Award (EIA)? This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement. Applications for the STAR program must be submitted in the second or third year of the current award. Applications will compete for available funds with all other recommended applications. The demands of childbirth and subsequent primary caregiving responsibilities may necessitate changes to career goals and alter researchers career trajectories, depriving the scientific workforce of an important source of talent and undermining NIH's investment in promising avenues of new research. Enhance investigators' ability to move into research areas that are distinct from those of their postdoctoral mentors by not requiring or expecting preliminary data, which could lead to new scientific discoveries. 3. Projects of limited time and scope that do not meet these characteristics of innovative, ground-breaking research should consider applying for a small Research Project Grant (Parent R01). If the goals of the MIRA have changed, complete section B.1.a. Applying for Subsequent Awards after Receiving a MIRA. I am thrilled to announce that I have been awarded a new @NIDDKgov /@NIH Stephen I. Katz Early-Stage Investigator Research Project Grant-R01 providing $2.3 million in funding over five years to advance our research efforts NIHTurning Discovery Into Health Is the overall strategy well-reasoned and appropriate to accomplish the overall goals of the research program? It qualifies only if all the PIs are ESI. This activity code is used in lieu of the UH2 activity code when larger budgets and/or project periods are required to establish feasibility for the project. Is the projected timeline feasible and well justified? 3. Requests related to lapses in funding and possible new directions will not be considered. In this case, the Clinical Research Education and Career Development (CRECD) grant awards support development and implementation of curriculum-dependent programs in minority institutions to train selected doctoral and postdoctoral candidates in clinical research leading to a Master of Science in Clinical Research or Master of Public Health in a clinically relevant area. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Notice of Change to PAR-23-024 -Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1- Clinical Trial Optional) (NOT-DK-23-020) National Institute of Diabetes and Digestive and Kidney Diseases. This grant supports the administrative planning and development of a clinical trial implementation cooperative agreement (U01). In Section C: Equipment Description, enter budget request for equipment. All NIH grant and cooperative agreement awards include theNIH Grants Policy Statement as part of the NoA. Refer to NIH's Early Stage Investigator policies for information about what awards impact ESI status. Please turn on JavaScript and try again. April Hearron. The supplement may be used to support additional personnel, computational services, supplies and equipment that will promote the continuity of the career development research project during a period in which the PD/PI experiences critical life events which have the potential to impact research progress or potential productivity. Paper applications will not be accepted. New and Early Stage Investigators A Program Director or Principal Investigator (PD/PI) is considered a New Investigator (NI) if he/she has not previously competed successfully as PD/PI for a significant NIH independent research award. The supplement is not retroactive. Telephone: 301-402-7469 or 866-504-9552 (Toll Free), General Grants Information (Questions regarding application instructions, application processes, and NIH grant resources) Plan to develop transdisciplinary collaboration(s) that require unique expertise and/or solicit diverse perspectives to address research question(s). The application budget cannot exceed a maximum direct cost of $70,000; applicable F & A (indirect) cost can also be requested. Examples of items that advance inclusivity in research and may be part of the PEDP can include, but are not limited to: For further information on the PEDP, please seehttps://braininitiative.nih.gov/about/pedp-key-elements-and-examples. If this letter is not included, the application will be considered incomplete and will not be reviewed.This information could include start-up packages and other institutional research support, space available to the PD/PI, salary support commitment for the PD/PI, skills and career development opportunities for the PD/PI, mentoring during the promotion and tenure process, and career advancement prospects for non-tenure track applicants. All instructions in the SF424 (R&R) Application Guide, PA-20-272 and NOT-OD-23-031 must be followed. Per the updated NIH Policy for Review and Resubmission of New Investigator R01 Applications, NI R01 applications will be reviewed on the same timeline as other applications submitted to the same FOA. Support will be provided for up to 2 years (R61 Phase) to perform critical experiments that rigorously test the proposed concept. Applicants are expected to provide an overview of the research program/scientific questions they plan to address and a general description of possible strategies; experimental details are not expected. Activation of the independent award phase is administrative, and is contingent upon the investigator securing an independent research position. Investigators with K awards from NIGMS will be required to relinquish the K award prior to the start date of the MIRA. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. 23. Review Branches (RBs) are clusters of study sections based on scientific discipline. For each budget period: 1. In Section A: Senior/Key Person, provide an entry for the PD/PI, including the appropriate level of effort, and enter $0 for Requested Salary and $0 for Fringe Benefits. 22. While a 10-year R&R Detailed Budget form is provided in the application package, applicants may not request more than 5 years of support. The PD/PI is required to devote at least 51% of their total research effort to this award. NINDS uses an extended R01 payline to make it easier for early-stage investigators to get an award, or put another way, to normalize the success rate of early-stage investigators so they have the same chance of success as established investigators. Anticipated Announcement and Award Dates. The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day. NIGMS recognizes that diverse teams working together and capitalizing on innovative ideas and distinct perspectives outperform homogeneous teams. Where applicable, Title XI and Section 1557 prohibit discrimination on the basis of sexual orientation, and gender identity. Exploratory/Developmental Cooperative Agreement Phase I, Exploratory/Developmental Cooperative Agreement Phase II. NIAMS has 2 receipt dates for this program: May 1st and Nov 1st. Applications must include a PEDP submitted as an Other Attachment on the SF424(R&R) Other Project Information form and an institutional letter of commitment submitted as a Letter of Support on the PHS 398 Research Plan form. Peer reviewers look more at your potential than achievementthey weigh your academic and research background heavily. For example, a program that by its nature is not innovative may be essential to advance a field. If you are early in your career you might also be able to participate in our Early Career Reviewer program. options to access the application forms for this opportunity. Has the PD/PI presented adequate plans to address relevant biological variables, such as sex, for studies in vertebrate animals or human subjects? Email:GrantsInfo@nih.gov(preferred method of contact) As applicable for the proposed research program, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score. Recipients must comply with any funding restrictions described in Section IV.6. Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIHs electronic system for grants administration.
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